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Bone ultrasonometry and turnover markers in primary hyperparathyroidism.
B Cortet1, C Cortet, F Blanckaert
1Department of Rheumatology, University-Hospital of Lille, F-59037 France.
Calcified Tissue International
|December 22, 1999
Summary
Quantitative ultrasound (QUS) is a useful tool for assessing bone health in mild primary hyperparathyroidism (PHPT). This study found QUS correlated with bone mineral density and bone remodeling markers in PHPT patients.
Area of Science:
- Endocrinology
- Bone Metabolism
- Medical Imaging
Background:
- Mild primary hyperparathyroidism (PHPT) effects on bone are not fully understood.
- Bone remodeling markers and quantitative ultrasound (QUS) have been under-investigated in mild PHPT.
Purpose of the Study:
- To evaluate the utility of QUS and bone remodeling markers in assessing bone status in patients with mild PHPT.
Main Methods:
- Quantitative ultrasound (QUS) measured bone ultrasound attenuation (BUA) and speed of sound (SOS) at the heel.
- Bone remodeling markers including bone alkaline phosphatase (BAP), osteocalcin (OC), and collagen cross-linked telopeptides (CTX) were assessed.
- Bone mineral density (BMD) was measured at the lumbar spine, femoral neck, and Ward's triangle.
Main Results:
- Significant differences were observed between PHPT patients and controls in BUA, BMD (lumbar spine, femoral neck, Ward's triangle), BAP, and OC (P < 0.05).
- Several bone turnover markers showed moderate correlations with QUS parameters (r = -0.39 to -0.55) and BMD (r = -0.48 to 0.63).
- Procollagen type I N- and C-terminal propeptides (PINP, PICP) were higher in PHPT patients, but not significantly.
Conclusions:
- Quantitative ultrasound (QUS) appears to be a relevant tool for evaluating bone status in individuals with mild primary hyperparathyroidism.
- QUS may aid in the assessment of bone health in conjunction with traditional BMD measurements and bone turnover markers.