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Dengue seroconversion among Israeli travelers to tropical countries
I Potasman1, I Srugo, E Schwartz
1Bnai Zion Medicla Center, Haifa, Israel. ipotasma@netvision.net.il
Emerging Infectious Diseases
|December 22, 1999
Summary
Dengue seroconversion occurred in 6.7% of young Israeli adults traveling abroad. Most dengue infections were asymptomatic, detected via immunoglobulin M or G antibodies, with Southeast Asia being a common travel destination.
Area of Science:
- Medical Entomology
- Tropical Medicine
- Immunology
Background:
- Dengue virus is a significant global health concern, particularly in tropical regions.
- Understanding seroconversion rates in travelers is crucial for assessing infection risk and public health strategies.
Purpose of the Study:
- To determine the incidence of dengue virus seroconversion in young Israeli adults undertaking extended travel to tropical areas.
- To characterize the clinical and serological profiles of travelers who seroconverted during their trips.
Main Methods:
- Prospective study involving 104 Israeli young adults traveling for at least 3 months.
- Serological testing for dengue virus immunoglobulin (Ig) M and IgG antibodies before and after travel.
- Clinical assessment of symptomatic individuals.
Main Results:
- Seven participants (6.7%) showed evidence of dengue seroconversion.
- Four individuals (3.8%) tested positive for dengue IgM antibodies.
- Two participants (1.9%) demonstrated a rise in IgG titers without detectable IgM, with one experiencing symptoms.
Conclusions:
- Young adults traveling to tropical countries have a notable risk of dengue virus infection.
- Many dengue infections in travelers may be asymptomatic or subclinical, highlighting the importance of serological surveillance.
- Southeast Asia emerged as a frequent destination for travelers who seroconverted, suggesting it as a high-risk area for dengue exposure.