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Ascorbic acid in cholesterol and bile acid metabolism.

E Ginter

    Annals of the New York Academy of Sciences
    |September 30, 1975
    PubMed
    Summary

    Chronic ascorbic acid deficiency in guinea pigs impairs cholesterol to bile acid conversion, leading to high cholesterol. High doses of ascorbic acid aid this process and lower human plasma cholesterol.

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    Area of Science:

    • Biochemistry
    • Metabolic disorders
    • Nutritional science

    Background:

    • Latent chronic ascorbic acid deficiency causes liver metabolic disorder in guinea pigs.
    • Impaired cholesterol transformation to bile acids leads to hypercholesterolemia and hepatic cholesterol accumulation.
    • Reduced cholesterol circulation release is observed.

    Purpose of the Study:

    • To investigate the role of ascorbic acid in cholesterol metabolism.
    • To understand the mechanism of impaired bile acid biosynthesis in ascorbic acid deficiency.
    • To evaluate the effect of high-dose ascorbic acid on cholesterol transformation.

    Main Methods:

    • Induction of latent chronic ascorbic acid deficiency in guinea pigs.
    • Analysis of liver and plasma cholesterol levels.
    • Monitoring of cholesterol transformation to bile acids.
    • Administration of high doses of ascorbic acid to guinea pigs and humans.

    Main Results:

    • Ascorbic acid deficiency provokes impaired cholesterol transformation to bile acids in guinea pigs.
    • This leads to hypercholesterolemia and hepatic cholesterol accumulation.
    • High doses of ascorbic acid significantly stimulate cholesterol transformation to bile acids in guinea pigs.
    • High doses of ascorbic acid decrease plasma cholesterol concentration in humans.

    Conclusions:

    • Ascorbic acid is crucial for efficient cholesterol transformation into bile acids.
    • The deficiency likely affects bile acid biosynthesis at the 7 alpha-hydroxylation stage.
    • Supplementation with high-dose ascorbic acid can improve cholesterol metabolism and reduce plasma cholesterol.

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