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Vestibular disorders in primary thrombocytosis.
M De Ciccio1, B Fattori, A Carpi
1Neuroscience Department, University of Pisa, Italy.
The Journal of Otolaryngology
|December 22, 1999
Summary
Balance disturbances are common in essential thrombocythaemia (ET) and polycythaemia vera (PV). This study found central vestibular system involvement in most patients with these myeloproliferative disorders.
Area of Science:
- Neurology
- Ophthalmology
- Otorhinolaryngology
Background:
- Balance disturbances are frequent symptoms in chronic myeloproliferative disorders (MPDs), particularly essential thrombocythaemia (ET) and polycythaemia vera (PV).
- These MPDs are characterized by high platelet counts, potentially impacting microcirculation and neurological function.
Purpose of the Study:
- To investigate vestibulo-oculomotor and vestibulospinal reflexes in patients with ET and PV.
- To identify the prevalence and nature of vestibular system involvement in these MPDs.
Main Methods:
- Evaluated 43 patients diagnosed with ET or PV.
- Conducted otoneurologic examinations focusing on vestibulo-oculomotor and vestibulospinal reflexes.
Main Results:
- Central vestibular system involvement was observed in 60.4% of patients.
- A combined peripheral and central involvement was found in 18.6% of cases.
- Purely peripheral involvement occurred in 1 patient, while 14% showed no alterations.
Conclusions:
- Balance disorders in ET and PV likely stem from microcirculatory issues related to platelet dysfunction.
- Central vestibular system involvement may be explained by increased availability of central serotonin as a neuromediator.