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Nutrition and immunity in the elderly.

B Lesourd1, L Mazari

  • 1Unité de Médecine Nutritionnelle Gériatrique, Hôpital Charles Foix, Ivry sur Seine, France. bruno.lesourd@cfx.ap-hop-paris.fr

The Proceedings of the Nutrition Society
|December 22, 1999
PubMed
Summary

Immune aging is characterized by dysregulation, not just decline. Environmental factors and nutrition significantly impact immune responses in the elderly, more than intrinsic changes.

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Nutrition: a major factor influencing immunity in the elderly.

The journal of nutrition, health & aging·2004

Area of Science:

  • Immunology
  • Gerontology

Background:

  • Immune function declines with age, increasing susceptibility to infections and cancer.
  • Immune aging involves progressive immune dysregulation rather than a uniform decline.
  • Cell-mediated immunity changes earlier and more significantly than humoral immunity with age.

Purpose of the Study:

  • To review innate and cell-mediated immune changes during aging.
  • To differentiate between primary (intrinsic) and secondary (environmental) immune changes.
  • To highlight the significant role of environmental factors and nutrition in elderly immune function.

Main Methods:

  • Review of existing literature on immune aging.
  • Analysis of age-related changes in T-cell subsets (naive:memory, mature:immature, T-helper 1:2).
  • Examination of innate immunity (macrophage function) and humoral immunity (CD5, antibody responses).

Main Results:

  • Innate immunity is preserved or enhanced in aging, unlike specific immunity.
  • Primary immune changes in healthy individuals have less impact than previously thought.
  • Secondary immune changes, driven by environmental factors (antigens, drugs, diet, activity), are more prevalent and impactful.

Conclusions:

  • Immune aging is primarily driven by secondary, environmentally induced dysregulations.
  • Nutritional status significantly influences immune responses in the elderly.
  • Understanding these changes is crucial for addressing age-related health issues.

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