Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selenium and host defence towards viruses.

M A Beck1

  • 1University of North Carolina at Chapel Hill 27599-7220, USA. melinda_beck@unc.edu

The Proceedings of the Nutrition Society
|December 22, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measurement of a superconducting qubit with a microwave photon counter.

Science (New York, N.Y.)·2018
Same author

Increased risk of influenza among vaccinated adults who are obese.

International journal of obesity (2005)·2017
Same author

Predicting total dissolved solids release from central Appalachian coal mine spoils.

Environmental pollution (Barking, Essex : 1987)·2016
Same author

Tissue factor deficiency increases alveolar hemorrhage and death in influenza A virus-infected mice.

Journal of thrombosis and haemostasis : JTH·2016
Same author

The effects of diet-induced obesity on B cell function.

Clinical and experimental immunology·2014
Same author

Obesity is associated with impaired immune response to influenza vaccination in humans.

International journal of obesity (2005)·2011
Same journal

Nutritional and dietary drivers in the pathogenesis of acute appendicitis: the nutrition-microbiome-genetic axis.

The Proceedings of the Nutrition Society·2026
Same journal

Redistributing power in food systems: How community-led responses move from crisis buffering to systems transformation.

The Proceedings of the Nutrition Society·2026
Same journal

Using positive social influences to increase children's vegetable intake.

The Proceedings of the Nutrition Society·2026
Same journal

Combining sequence-based approaches with anaerobic microbiology and modelling to understand gut microbial communities.

The Proceedings of the Nutrition Society·2026
Same journal

Misled or misfed: Nutrition claims targeting active females on social media, is there research evidence to support them?

The Proceedings of the Nutrition Society·2026
Same journal

Whole-body metabolic modelling and its prospects in precision nutrition.

The Proceedings of the Nutrition Society·2026
See all related articles

Host nutrition impacts viral virulence. Nutritional deficiencies, like low selenium or vitamin E, can genetically alter viruses, making them virulent and increasing disease susceptibility in all hosts.

Area of Science:

  • Virology
  • Nutritional Immunology
  • Molecular Biology

Background:

  • The link between viral diseases and nutrition traditionally focuses on host immune system compromise.
  • Malnutrition weakens the host immune system, increasing susceptibility to viral infections.

Purpose of the Study:

  • To investigate how host nutritional status affects viral virulence beyond immune suppression.
  • To explore the potential for viruses to undergo genetic changes influenced by host nutrition.

Main Methods:

  • Utilizing selenium-deficient and vitamin E-deficient mouse models.
  • Inoculating mice with a normally benign coxsackievirus B3 (CVB3/0) strain.
  • Sequencing viral genomes to identify mutations in viruses replicated in deficient hosts.
  • Experimenting with glutathione peroxidase (EC 1.11.1.9)-knockout mice.

Related Experiment Videos

Main Results:

  • Coxsackievirus B3 (CVB3/0) acquired virulence in Se-deficient and vitamin E-deficient mice.
  • Six nucleotide changes were identified in the virus replicating in deficient mice.
  • These viral genomic alterations rendered the virus virulent even in normally nourished mice.
  • Benign virus also converted to virulence with genomic changes in glutathione peroxidase-knockout mice.

Conclusions:

  • Host nutritional status can transform an avirulent virus into a virulent one through genetic mutation.
  • Oxidative stress is proposed as a common mechanism underlying these virus-induced genetic changes.
  • Vitamin E and selenium, acting as antioxidants, play a critical role in preventing viral genome alteration.
  • Host nutrition is crucial for managing viral diseases, impacting both the host and the viral pathogen.