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Published on: April 21, 2015
Lymphocytic colitis, induced by ticlopidine
G E Feurle1, K O Bartz, A Schmitt-Gräff
1DRK-Krankenhaus Neuwied. Germany.
Zeitschrift Fur Gastroenterologie
|December 22, 1999
Summary
Lymphocytic colitis, a chronic diarrhea condition, may be triggered by medications. Stopping ticlopidine resolved a patient's colitis, suggesting drug history is key for treating this disorder.
Area of Science:
- Gastroenterology
- Immunology
- Colorectal Diseases
Background:
- Lymphocytic colitis is a chronic inflammatory condition of the colon.
- It presents with watery diarrhea and increased lymphocytes in the colonic lining.
- The exact cause remains unknown, with theories involving immune responses to bacteria, diet, or autoimmune factors.
Observation:
- A patient presented with classic lymphocytic colitis features.
- This patient exhibited a significant intraepithelial T-cell presence.
- Colitis symptoms completely resolved after discontinuing ticlopidine therapy.
Findings:
- Ticlopidine, an antiplatelet agent, was identified as a potential trigger.
- Cessation of ticlopidine led to complete remission of lymphocytic colitis.
- This suggests a drug-induced etiology in some cases.
Implications:
- Patient drug history is crucial for diagnosing lymphocytic colitis.
- Identifying and removing causative drugs may offer a cure for this condition.
- This highlights the importance of considering medication side effects in inflammatory bowel diseases.
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