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[Male predominance and birth weight in hypertrophic pyloric stenosis]
1Hospital de Especialidades 1, Centro Médico Nacional Noroeste, Instituto Mexicano del Seguro Social, Ciudad Obregón, Sonora, México. Illalex@infosel.net.mx
Insights
Male predominance in infantile hypertrophic pyloric stenosis (IHPS) is linked to higher birthweights. This male-to-female disparity in IHPS cases emerges specifically in newborns weighing 3,000 grams or more.
Area of Science:
- Pediatrics
- Gastroenterology
- Medical Genetics
Background:
- Infantile hypertrophic pyloric stenosis (IHPS) is a common yet poorly understood condition.
- IHPS incidence is higher in male infants and those with greater birthweights.
- Family history also correlates with increased IHPS risk.
Purpose of the Study:
- To investigate the relationship between IHPS and male predominance.
- To analyze how birthweight influences the male-to-female ratio in IHPS cases.
Main Methods:
- Retrospective review of 115 IHPS patient charts.
- Stratification of cases by infant gender and birthweight (in 500g increments from 1,500g to 3,500g).
- Statistical analysis using chi-square and proportion comparison tests.
Main Results:
- Male predominance was not observed in IHPS infants with birthweights of 2,500g or less.
- The male-to-female ratio increased with birthweight, reaching 8.8:1 for infants weighing 3,500g or more (p < 0.005).
- A significantly higher proportion of male infants had birthweights of 3,000g or more compared to females (82.6% vs. 52.1%, p < 0.005).
Conclusions:
- The male excess in IHPS cases is primarily associated with newborns weighing 3,000g or more.
- This birthweight-dependent male predominance is not observed in female infants with IHPS.
Background:
Infantile hypertrophic pyloric stenosis (IHPS), although fairly frequent, is still an enigmatic disease. Its incidence is increased among relatives of a case and among infants of male sex (M) and of high birthweight. The purpose of this paper is to analyze the pattern of IHPS M predominance according to birthweight (BW).
Methods:
115 consecutive cases charts of IHPS were reviewed and stratified by gender and BW rank (500 g each, beginning at 1,500 g and ending at 3,500 g). Statistical analysis was done by means of chi square and comparation of proportions tests.
Results:
M predominance was not observed in IHPS patients with a BW of 2,500 g or less (n = 11, 6M). Female infants (F) did not increase their number of cases as the BW rose, but M did, reaching an 8.8 to 1 M to F ratio among those with a BW of 3,500 9 or more (p < 0.005). The proportion of M with a BW of 3,000 g or more was significantly higher than in F (0.826 vs. 0.521, p < 0.005).
Conclusions:
In IHPS, the excess of M cases, which is responsible of the M/F disparity, is present only among newborns with a BW of 3,000 g or more. The disease does not show this relation to BW in F.