Schistosoma mansoni: testis alterations induced by antischistosomal drug Ro15-5458

Effects of the administration of curative and subcurative doses of antischistosomal drug (Ro15-5458) on the testis of Schistosoma mansoni were studied using electron microscopy. Worms were recovered from mice one day and seven days after treatment. Testis alterations included disintegration of the non-germinal cells, detachment of the muscle fibres from the basal lamina, cellular shrinkage, disorganization of the germ cells, vacuolation within the testis and regression of spermatocytes. Degrees of lesion intensity were clearly depending on the period of recovery after treatment and on the dosage.