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Redox regulation of signal transduction in mammalian cells
1Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, and University of Karlsruhe, Institute of Genetics, Germany. genetik@igen.fzk.de
Biochemical Pharmacology
|December 22, 1999
Abstract:
This mini-review addresses the mechanism of ultraviolet-light-induced activation of receptor tyrosine kinases. The experimental approach into this mechanism revealed the existence of redox regulation of signal transduction in mammalian cells. It is postulated that, in addition to responsiveness to oxidative attacks from outside, redox regulation of specific redox-sensitive proteins likely represents an important physiological mechanism.