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B-cell commitment: Pax5 is the deciding factor
1Section of Gene Function and Regulation, Chester Beatty Laboratories, Institute of Cancer Research, London, SW3 6JB, UK. tariq@icr.ac.uk
Current Biology : CB
|December 23, 1999
Abstract:
Recent studies have identified the transcription factor Pax5 as a critical determinant of commitment to the B-lymphocyte pathway. Surprisingly, Pax5 appears to achieve this primarily through suppressing alternative haematopoietic lineage fates.