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Related Experiment Videos

Coding sequence evolution.

M Kreitman1, J M Comeron

  • 1Department of Ecology and Evolution, University of Chicago, Chicago, 60637, USA. mkre@midway.uchicago.edu

Current Opinion in Genetics & Development
|December 23, 1999
PubMed
Summary

Recent advances in molecular evolution techniques have improved codon usage understanding but not protein evolution. New methods promise to change this, impacting the study of protein evolution.

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Area of Science:

  • Evolutionary biology
  • Molecular evolution
  • Genomics

Background:

  • Statistical and experimental techniques for molecular evolution have advanced significantly over the last decade.
  • These methods have greatly enhanced understanding of selection for codon usage in coding DNA regions.

Purpose of the Study:

  • To highlight the limited impact of recent molecular evolution techniques on protein evolution studies.
  • To suggest that this limitation is about to change with new developments.

Main Methods:

  • Review of statistical and experimental techniques in molecular evolution.
  • Analysis of the application of these techniques to coding regions.
  • Assessment of their impact on understanding codon usage versus protein evolution.

Main Results:

  • Remarkable advances in understanding selection for codon usage.
  • Limited impact on the understanding of protein evolution despite methodological progress.

Conclusions:

  • Despite progress in molecular evolution, protein evolution remains less understood.
  • Emerging techniques are poised to significantly advance the study of protein evolution.

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