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mRNA localization: motile RNA, asymmetric anchors
1Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280, USA. Kerry_Bloom@unc.edu
Current Opinion in Microbiology
|December 23, 1999
Abstract:
Techniques to label mRNA with green fluorescent protein (GFP) have provided the first real-time images of RNA motility in live yeast cells. Genetic screens for factors responsible for mRNA asymmetry (e. g. SHE genes) in yeast identified type V myosin among other proteins. Analysis of mRNA movement in various she mutants revealed the role of motor proteins in long-range transport, factors for particle formation, and cortical anchors for docking the mRNA.