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Novel ways to prevent proteolysis - prophytepsin and proplasmepsin II
1Department of Biochemistry, Medical Research Council Group in Protein Structure and Function, University of Alberta, Edmonton, T6G 2H7, Canada.
Current Opinion in Structural Biology
|December 23, 1999
Abstract:
The recently determined crystal structures of two aspartic proteinase zymogens, prophytepsin from barley and proplasmepsin II from the malarial parasite Plasmodium falciparum, have provided new insights into zymogen inactivation. Prophytepsin shows a variation of the mechanism of inhibition used by the well-known gastric aspartic proteinase zymogens, whereas proplasmepsin II uses a completely new mode of inactivation.