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Related Experiment Videos

Gene therapy with herpes simplex virus vectors.

D S Latchman1

  • 1Department of Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, UK.

Archivum Immunologiae Et Therapiae Experimentalis
|December 23, 1999
PubMed
Summary

Herpes simplex virus vectors show promise for gene therapy in the nervous system, offering a way to deliver genes to non-dividing cells for intractable neurological diseases. Research is advancing disablement and long-term expression for potential human applications.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Gene Therapy

Background:

  • Gene delivery to the nervous system is challenging due to its complexity and the need to target non-dividing cells.
  • Intractable neurological diseases require innovative therapeutic strategies.
  • Herpes simplex virus (HSV) offers unique advantages for neural gene delivery.

Purpose of the Study:

  • To evaluate the potential of herpes simplex virus as a vector for gene therapy in the nervous system.
  • To highlight the advantages of HSV, including its large genome and latency in neurons.
  • To discuss the progress in modifying HSV for safe and effective gene delivery.

Main Methods:

  • Modification of herpes simplex virus to disable its pathogenicity while retaining gene delivery capabilities.

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  • Development of systems for long-term expression of foreign genes within neuronal cells.
  • Ongoing testing in preclinical models, including rodent and primate studies.

    • Main Results:

    • Significant progress has been made in disabling herpes simplex virus for gene therapy applications.
    • Demonstrated ability of modified HSV to achieve long-term expression of therapeutic genes.
    • HSV vectors show potential for targeting non-dividing neuronal cells.

    Conclusions:

    • Herpes simplex virus vectors hold significant promise for treating intractable neurological diseases.
    • Further research is needed to fully disable the virus and conduct extensive preclinical testing.
    • Modified HSV vectors are likely to become valuable tools in human gene therapy for neurological disorders.