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Respiratory viruses and asthma.

R S Peebles¹, T V Hartert

¹Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-2650, USA.

Current Opinion in Pulmonary Medicine

|December 23, 1999

Summary

Viral infections significantly worsen asthma exacerbations, but treatments lag behind diagnostic advances. Further research is needed to understand how viruses trigger asthma and develop effective therapies.

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Area of Science:

* Respiratory viral infections
* Asthma and airway hyperresponsiveness

Background:

* Viral infections are a major trigger for asthma exacerbations.
* Diagnostic capabilities for viruses have advanced, but specific treatments and management strategies for virus-induced asthma morbidity have not progressed comparably.
* This gap highlights a critical need for improved understanding and intervention.

Purpose of the Study:

* To review current knowledge on the epidemiology of viruses in asthma exacerbations.
* To examine the physiological and immunological effects of viral infections on asthma.
* To discuss potential therapeutic strategies for mitigating virus-induced airway hyperresponsiveness.

Main Methods:

* Literature review and synthesis of current research concepts.
* Focus on epidemiological data, physiological and immunological consequences.
* Exploration of potential therapeutic targets and approaches.

Main Results:

* Viruses are increasingly identified as key contributors to asthma exacerbations.
* The mechanisms by which viruses induce airway reactivity require further elucidation.
* Current therapeutic options are limited in addressing virally-induced asthma complications.

Conclusions:

* Understanding the precise mechanisms of virus-induced airway reactivity is crucial.
* Development of rational and safe preventative and therapeutic strategies is essential.
* Addressing viral triggers is vital for managing asthma morbidity and improving patient outcomes.

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