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Sequence evidence for an altered genetic code in the Neospora caninum plastid
1Department of Medicine, University of Alabama at Birmingham, 35294-2170, USA. nlang-unnasch@geomed.dom.uab.edu
International Journal for Parasitology
|December 23, 1999
Abstract:
The plastid DNA of Neospora caninum encodes a homologue of the rpoB gene, which is believed to encode a subunit of a bacterial or chloroplast-like RNA polymerase. The predicted protein product of the N. caninum rpoB gene has three in-frame UGA codons which appear to encode tryptophan residues rather than act as stop codons. Based on the nucleotide sequence of a portion of the ssrRNA gene of the N. caninum plastid, a model for suppression of UGA termination in this plastid is presented.