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A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
18:11

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

Myocardial perfusion abnormalities in treated hypertensive patients without known coronary artery disease

A Elhendy1, R T van Domburg, J J Bax

  • 1Thoraxcenter, University Hospital Rotterdam-Dijkzigt, Rotterdam, The Netherlands. elhendya@hotmail.com

Journal of Hypertension
|December 23, 1999
PubMed

Insights

Hypertensive patients without coronary artery disease show similar myocardial perfusion abnormalities as normotensive individuals. This finding suggests hypertension does not independently increase perfusion defects in this population.

Area of Science:

  • Cardiology
  • Nuclear Medicine
  • Cardiovascular Imaging

Background:

  • Hypertension is a risk factor for cardiovascular disease.
  • Myocardial perfusion abnormalities can occur in hypertension even without significant coronary artery disease.
  • The comparative prevalence of these abnormalities in hypertensive versus normotensive patients with similar clinical features is not well-established.

Purpose of the Study:

  • To compare the prevalence and extent of myocardial perfusion abnormalities at rest and during stress in patients with and without hypertension.
  • To evaluate myocardial ischemia using dobutamine stress technetium-99m myocardial perfusion SPECT imaging.

Main Methods:

  • Dobutamine stress technetium-99m myocardial perfusion SPECT imaging was performed in 350 patients without known coronary artery disease.
  • 148 patients were hypertensive; rest SPECT images were acquired 24 hours post-stress.
  • Abnormal perfusion was defined as reversible or fixed perfusion defects.

Main Results:

  • No significant differences were found between hypertensive and normotensive groups in gender, symptoms, risk factors, or pretest probability of coronary artery disease.
  • Hypertensive patients were older and more frequently on beta-blockers.
  • The prevalence and severity of myocardial perfusion abnormalities (rest and stress) were similar between the hypertensive and normotensive groups across all pretest probability categories.

Conclusions:

  • Treated hypertensive patients without known coronary artery disease exhibit similar prevalence and severity of myocardial perfusion abnormalities compared to normotensive patients.
  • These findings indicate that hypertension, in the absence of known coronary artery disease, does not significantly increase myocardial perfusion abnormalities at rest or during dobutamine stress.
  • Clinical characteristics similarity is key for this comparison.
Abstract

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