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Non-typhi Salmonella bacteremia in children
1Department of Internal Medicine, University of Pittsburgh Medical Center, Mckeesport, PA, USA.
The Pediatric Infectious Disease Journal
|December 23, 1999
Summary
Non-typhi Salmonella (NTS) bacteremia in children often shows persistent bacteremia, regardless of antibiotic choice. While focal infections are rare in healthy children, they are more common in those with underlying conditions.
Area of Science:
- Pediatric Infectious Diseases
- Bacteriology
- Clinical Microbiology
Background:
- Non-typhi Salmonella (NTS) infections commonly cause self-limited diarrhea in children.
- Bacteremia is a recognized complication of NTS, yet management guidelines are based on limited evidence.
- Understanding NTS bacteremia outcomes is crucial for pediatric patient care.
Purpose of the Study:
- To investigate the clinical outcomes of pediatric patients diagnosed with NTS bacteremia.
- To analyze factors influencing persistent bacteremia and focal infection development.
- To inform clinical management strategies for NTS bacteremia in children.
Main Methods:
- A 16-year retrospective review of pediatric patients with NTS bacteremia at an urban hospital.
- Abstraction of clinical data from initial visits, follow-up visits, and hospitalizations.
- Analysis of patient demographics, treatment, and complication development.
Main Results:
- 144 pediatric patients with NTS bacteremia were identified; median age was 10.5 months.
- Persistent bacteremia occurred in 41% of patients; no clinical factors predicted this.
- Focal infections developed in 2.5% of healthy children versus 36% of those with underlying conditions.
Conclusions:
- NTS bacteremia can occur in healthy children, with a low risk of focal infections.
- Persistent bacteremia is common in pediatric NTS cases, irrespective of initial antibiotic therapy.
- Children with underlying medical conditions face a significantly higher risk of focal NTS infections.