The transfer of passive immunity to the foal and its relation to immune status after birth

The mechanism of transfer of maternal immunity to the foal is reviewed. Maximal efficiency of macromolecular absorption by specialized cells of the small intestine exists soon after birth. The absorptive cells are progressively replaced by more mature-looking cells incapable of taking up large molecules and the rate of absorption is reduced in a linear decline and ceases completely within 24 hr. Passive antibody levels fall rapidly in the first 4 weeks of life to less than half their original values and have usually completely disappeared by 6 months of age. The foal shows immunological competence soon after birth although appreciable levels of autogenous immunoglobulins are not usually attained until 2 to 3 months of age.