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Related Experiment Videos

Do tricyclic responders have different brain laterality?

J W Stewart1, F M Quitkin, P J McGrath

  • 1Depression Evaluation Service, New York State Psychiatric Institute, New York 10032, USA.

Journal of Abnormal Psychology
|December 28, 1999
PubMed
Summary
This summary is machine-generated.

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Depression treatment with imipramine showed poorer left-ear accuracy for consonant-vowel (CV) tests in responders, suggesting right-hemisphere dysfunction. Placebo responders also showed improved CV test performance.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Previous research indicated right-hemisphere dysfunction in depressed patients responding to tricyclic antidepressants.
  • This dysfunction was suggested by dichotic complex tones test results in a prior study.

Purpose of the Study:

  • To investigate hemispheric processing differences in depressed patients undergoing treatment.
  • To examine the effects of imipramine and placebo on dichotic test performance in relation to treatment response.

Main Methods:

  • Sixty-eight depressed patients underwent dichotic consonant-vowel (CV) and complex tones (CT) testing.
  • Patients were subsequently treated with either imipramine or a placebo.
  • Performance on the dichotic tests was analyzed in relation to treatment response and medication group.

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Main Results:

  • A significant interaction revealed poorer left-ear accuracy for CV tests in imipramine responders compared to nonresponders, placebo responders, and controls.
  • Placebo responders demonstrated significantly greater left-ear CV accuracy than placebo nonresponders and controls.
  • Evidence of right-hemisphere dysfunction was observed for CV tests in imipramine responders, but not for CT tests.

Conclusions:

  • Treatment response to imipramine in depression is associated with altered left-hemisphere processing, specifically for consonant-vowel stimuli.
  • The findings partially replicate previous work, highlighting a test-specific effect on hemispheric lateralization.
  • Further research is needed to elucidate the precise mechanisms of antidepressant action on auditory processing and hemispheric function.