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Age-related permeability changes in rabbit corneas.

T L Ke¹, A F Clark, R W Gracy

¹Alcon Laboratories, Inc., Fort Worth, Texas 76134, USA.

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics

|December 28, 1999

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Corneal drug penetration significantly decreases with aging in rabbits, impacting delivery efficiency. This age-related decline varies based on compound properties and corneal integrity.

Area of Science:

Ophthalmology
Pharmacology
Biomedical Science

Background:

Corneal drug delivery is crucial for treating eye diseases.
Understanding age-related changes in corneal permeability is essential for optimizing drug efficacy.

Purpose of the Study:

To investigate the effect of aging on the corneal penetration of various compounds.
To determine how physicochemical properties and corneal integrity influence age-related differences in permeability.

Main Methods:

Utilized in vitro diffusion cells for passive transport under steady-state conditions.
Measured compound permeability across young (6 weeks) and old (3-4 years) rabbit corneas (intact and denuded).
Assessed a range of compounds with diverse lipophilicity and molecular weights.

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Main Results:

A significant decrease in corneal permeability was observed in aged corneas compared to young corneas.
The age-related difference in permeability was more pronounced for large hydrophilic compounds than small lipophilic ones in intact corneas.
The permeability difference between young and old denuded corneas was consistently around 2-fold.

Conclusions:

Aging significantly alters corneal permeability, affecting drug and nutrient transport.
Fundamental biochemical differences exist between young and aged corneas.
Findings provide insights for developing improved strategies for corneal drug and nutrient delivery.