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Related Experiment Videos

Lung transplantation--10-year experience.

W Harringer1, K Wiebe, M Strüber

  • 1Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Germany. harringer@thg.mh-hannover.de

European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-Thoracic Surgery
|December 28, 1999
PubMed
Summary

Lung transplantation provides a viable treatment option, demonstrating good early and midterm survival rates for various conditions. However, long-term success is challenged by chronic graft dysfunction, particularly obliterative bronchiolitis.

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Area of Science:

  • Cardiology
  • Pulmonology
  • Transplant Surgery

Background:

  • Lung transplantation has evolved significantly since its inception.
  • Various procedures including heart-lung, double lung, and single lung transplants are performed.

Purpose of the Study:

  • To review and discuss institutional experience with lung transplantation.
  • To analyze outcomes and survival rates across different transplant types and patient indications.

Main Methods:

  • Retrospective review of 282 lung transplant procedures (heart-lung, double lung, single lung) performed between December 1987 and September 1998.
  • Analysis of patient demographics, indications for transplantation, and survival data.

Main Results:

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  • Overall 1-, 3-, and 5-year survival rates were 77%, 70%, and 63%.
  • No significant difference in 1-year survival between heart-lung, double lung, and single lung transplants.
  • Higher 1-year survival observed in patients with cystic fibrosis, pulmonary fibrosis, obstructive lung disease, and Eisenmenger's syndrome compared to primary pulmonary hypertension.
  • Key causes of death included sepsis and obliterative bronchiolitis; 5-year freedom from bronchiolitis obliterans syndrome (BOS) was 45%.

    • Conclusions:

    • Lung transplantation is a valuable therapeutic option with favorable early and midterm outcomes.
    • Chronic graft dysfunction, specifically BOS, remains a significant impediment to long-term patient benefit.