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The role of RXR-alpha in retinoic acid-induced cleft palate as assessed with the RXR-alpha knockout mouse
P Nugent1, H M Sucov, M M Pisano
1Department of Molecular, Cellular and Craniofacial Biology, University of Louisville School of Dentistry and University of Louisville Birth Defects Center, KY 40292, USA. pfnuge01@gwise.louisville.edu
The International Journal of Developmental Biology
|December 28, 1999
Abstract:
Treatment of pregnant mice with retinoic acid (RA) in mid-gestation produces cleft palate and limb defects in the fetuses. RXR-alpha has been previously shown to mediate the teratogenic effects of RA in the limb. In this study, we show that RXR-alpha is also involved in retinoid-induced palatal clefting. Treatment of RXR-alpha knockout mice with a teratogenic dose of RA on gestation day 11 or 12 induces cleft palate at a lower frequency than that seen in wild-type animals.