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Related Experiment Videos

Differential memory span--abnormal lateralization pattern in schizophrenic patients and their siblings?

P Franke1, M Gänsicke, S Schmitz

  • 1Department of Psychiatry, University of Bonn, Germany. franke@uni-bonn.de

International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology
|December 28, 1999
PubMed
Summary

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Schizophrenia patients show impaired verbal memory, specifically in recalling recurring digits, suggesting a left-temporohippocampal deficit. This memory impairment may indicate a liability to schizophrenia in affected individuals and their siblings.

Area of Science:

  • Neuropsychology
  • Cognitive Neuroscience
  • Psychiatry

Background:

  • Schizophrenia is associated with temporohippocampal dysfunction.
  • The recurring digit span test is hypothesized to assess left-temporohippocampal functioning.
  • The recurring block span test is proposed to assess right-temporohippocampal functioning.

Purpose of the Study:

  • To investigate memory impairments in schizophrenia using recurring digit and block span tests.
  • To differentiate between left- and right-temporohippocampal functioning in schizophrenia.
  • To identify potential memory markers for schizophrenia liability.

Main Methods:

  • Administered recurring digit span and recurring block span tests to 106 acute schizophrenic patients, 49 siblings, and 53 controls.

Related Experiment Videos

  • Compared performance across groups to identify task-specific deficits.
  • Analyzed cumulative learning curves for verbal material.

    • Main Results:

    • Schizophrenic patients exhibited significantly reduced performance on the recurring digit span test compared to controls.
    • Performance differences between schizophrenic patients and controls were not significant for the recurring block span test.
    • Siblings at risk for schizophrenia also showed deficits in the recurring digit span test but not the recurring block span test.

    Conclusions:

    • Findings suggest a task-specific verbal memory impairment in schizophrenia, linked to left-temporohippocampal functioning.
    • The recurring digit span deficit may serve as a marker for schizophrenia liability.
    • Results support the role of left-sided temporohippocampal abnormalities in the etiology of schizophrenia.