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Related Experiment Videos

Central adenosine A(2A) receptors: an overview.

J L Moreau1, G Huber

  • 1Pharma Division, Preclinical CNS Research, F. Hoffmann-La Roche, PRPN, 72/141, CH-4070, Basel, Switzerland. jean-luc.moreau@roche.com

Brain Research. Brain Research Reviews
|December 28, 1999
PubMed
Summary

Central adenosine A(2A) receptors are key in brain function and disease. Targeting these receptors with antagonists or agonists may offer new treatments for neurodegenerative disorders, seizures, and sleep conditions.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Molecular Biology

Background:

  • Adenosine A(2A) receptors are a significant class of adenosine receptors within the brain.
  • Their highest expression is observed in the striatum, nucleus accumbens, and olfactory tubercles.
  • These receptors are Gs-coupled, activating adenyl cyclase.

Purpose of the Study:

  • To review the characteristics, distribution, and pharmacochemical properties of central adenosine A(2A) receptors.
  • To explore the regulation and A(2A) receptor-mediated behavioral responses.
  • To discuss the potential role of A(2A) receptors in neuropsychiatric disorders.

Main Methods:

  • Literature review integrating advances in molecular biology, biochemistry, cell biology, and behavioral pharmacology.

Related Experiment Videos

  • Analysis of selective ligands for adenosine receptors.
  • Examination of receptor interactions, particularly with dopamine D(2) receptors.

    • Main Results:

    • Adenosine A(2A) receptor stimulation reduces dopamine D(2) receptor agonist affinity, indicating antagonistic interactions.
    • A(2A) receptors are implicated in various physiological and pathological brain functions.
    • Expression is widespread, including neurons and microglia in most brain regions.

    Conclusions:

    • Adenosine A(2A) receptor antagonists show promise for treating neurodegenerative diseases like Parkinson's and cerebral ischemia.
    • Adenosine A(2A) receptor agonists may be beneficial for managing seizures and sleep disorders.
    • Further understanding of A(2A) receptors is crucial for developing novel neuropsychiatric therapeutics.