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Updated: Aug 17, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
Published on: May 6, 2014
Plasma sialyltransferase activity in healthy subjects and atherosclerotic patients
E V Gracheva1, N K Golovanova, M V Ezhov
1Institute of Experimental Cardiology, Cardiology Research Center, Russian Ministry of Health, Moscow, 121552, Russia.
Abstract:
Plasma sialyltransferase activity measured by incorporation of cytidine 5;-phospho[14C]acetylneuraminic acid (CMP-NeuAc) into asialofetuin was twofold higher in patients with documented atherosclerosis than in healthy donors. Kinetic studies showed that the enzyme affinity for CMP-NeuAc is the same in donors and patients. Low activity of plasma sialyltransferase in donors may be due to low blood content of this enzyme.
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