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Related Experiment Videos

Cell adhesion: old and new questions.

R O Hynes1

  • 1Howard Hughes Medical Institute and Center for Cancer Research, Dept of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. rohynes@mit.edu

Trends in Cell Biology
|December 28, 1999
PubMed
Summary

Cell adhesion is vital for multicellular organisms, enabling structural integrity and intercellular communication. This review explores the molecular mechanisms, biological roles, and evolutionary aspects of cell adhesion molecules.

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Evolutionary Biology

Background:

  • Cell adhesion is essential for metazoan survival, providing structural integrity.
  • Adhesion receptors link the extracellular matrix and cytoskeleton, acting as signal transducers.

Purpose of the Study:

  • Summarize current understanding of cell adhesion's molecular basis and biological consequences.
  • Discuss specificity, evolution, and inter-relationships with cell communication.

Main Methods:

  • Review of existing literature on cell adhesion molecules and processes.
  • Exploration of evolutionary pathways and signaling functions.

Main Results:

  • Cell adhesion involves transmembrane connections and signal transduction.
  • Understanding adhesion specificity is crucial.

Conclusions:

  • Cell adhesion is a complex process with significant evolutionary implications.
  • Further research is needed in the postgenomic era to address unresolved questions.

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