Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic instability and darwinian selection in tumours.

D P Cahill1, K W Kinzler, B Vogelstein

  • 1Program in Human Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

Trends in Cell Biology
|December 28, 1999
PubMed
Summary

Genetic instability, a key cancer feature, arises early in tumor formation. This instability fuels cancer progression by creating mutations that give cancer cells a growth advantage.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erratum to "Annotated normal CT data of the abdomen for deep learning: Challenges and strategies for implementation" [Diagn. Interv. Imaging. 101 (2020) 35-44].

Diagnostic and interventional imaging·2020
Same author

Differentiating autoimmune pancreatitis from pancreatic ductal adenocarcinoma with CT radiomics features.

Diagnostic and interventional imaging·2020
Same author

Deep lessons learned: Radiology, oncology, pathology, and computer science experts unite around artificial intelligence to strive for earlier pancreatic cancer diagnosis.

Diagnostic and interventional imaging·2019
Same author

Annotated normal CT data of the abdomen for deep learning: Challenges and strategies for implementation.

Diagnostic and interventional imaging·2019
Same author

Circulating tumor DNA as a potential marker of adjuvant chemotherapy benefit following surgery for localized pancreatic cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2019
Same author

Circulating tumor DNA as an early marker of therapeutic response in patients with metastatic colorectal cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2015

Area of Science:

  • Oncology
  • Genetics
  • Cancer Biology

Background:

  • Genetic instability is a long-hypothesized hallmark of cancer.
  • Emerging evidence suggests that mutations causing instability occur early in tumor development.

Purpose of the Study:

  • To discuss the role of genetic instability in cancer formation.
  • To outline future research directions for the genetic instability hypothesis.

Main Methods:

  • Review of existing literature on genetic instability and cancer.
  • Synthesis of current understanding of mutational processes in tumorigenesis.

Main Results:

  • Genetic instability is proposed to occur early in tumor formation.
  • Instability drives tumor progression through mutations in key genes.

Related Experiment Videos

  • Mutations confer a selective growth advantage, leading to clonal outgrowth.

    • Conclusions:

    • Genetic instability plays a critical role in the initiation and progression of cancer.
    • Further research is needed to solidify the genetic instability hypothesis in cancer development.