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[Streptokinase-induced jaundice].

J A Gómez Guindal1, I Roldán Rabadán, J Perea Egido

  • 1Unidad Coronaria, Hospital Universitario La Paz, Madrid.

Revista Espanola De Cardiologia
|December 28, 1999
PubMed
Summary
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This study reports a rare case of jaundice in a patient treated with streptokinase for acute myocardial infarction. The condition resolved within eight days, highlighting a potential, infrequent side effect of this common thrombolytic therapy.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Streptokinase is a widely used thrombolytic agent for acute myocardial infarction (AMI).
  • Early reperfusion therapy is crucial in managing AMI.
  • Systemic administration of streptokinase is a common treatment modality.

Observation:

  • A 35-year-old male presented with inferior AMI and received systemic streptokinase.
  • Six hours post-treatment, the patient developed fever, hepatomegaly, jaundice, and dark urine.
  • Laboratory tests revealed leukocytosis and elevated bilirubin levels.

Findings:

  • The patient's symptoms, including jaundice, indicated a potential adverse reaction to streptokinase.
  • Liver function tests showed transient enzymatic elevation and hyperbilirubinemia.
  • The condition showed progressive improvement, with complete symptom resolution by day eight.

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Implications:

  • This case underscores the rare occurrence of jaundice as a secondary effect of streptokinase.
  • Awareness of this potential adverse event is important for clinicians managing AMI patients.
  • Further investigation into the mechanisms of streptokinase-induced hepatotoxicity may be warranted.