Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone marrow: target for gene transfer.

S L Kirby1

  • 1University of North Carolina, Chapel Hill School of Medicine, USA.

Hospital Practice (1995)
|December 28, 1999
PubMed
Summary

Hematopoietic stem cells are ideal for gene therapy due to their self-replication and ability to generate all blood cells. This offers a lifelong source of therapeutic genes for various genetic disorders.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transdermal nicotine patches do not cause clinically significant gastroesophageal reflux or esophageal motor disorders.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco·2000
Same author

Comparison of granulocyte colony-stimulating factor (G-CSF)--mobilized peripheral blood progenitor cells and G-CSF--stimulated bone marrow as a source of stem cells in HLA-matched sibling transplantation.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation·2000
Same author

Impact of marketing work-place diversity on employee job involvement and organizational commitment.

The Journal of social psychology·2000
Same author

The therapeutic potential of erythropoietin receptor transgenes.

Cytokines, cellular & molecular therapy·1999
Same author

Murine T lymphocytes incapable of producing macrophage inhibitory protein-1 are impaired in causing graft-versus-host disease across a class I but not class II major histocompatibility complex barrier.

Blood·1998
Same author

Attitudes of white American male students toward work force diversity programs.

The Journal of social psychology·1998

Area of Science:

  • Biomedical research
  • Gene therapy
  • Stem cell biology

Background:

  • Marrow cells are the primary target in current human gene therapy trials.
  • Hematopoietic stem cells (HSCs) possess unique properties for therapeutic applications.

Purpose of the Study:

  • To evaluate the potential of hematopoietic stem cells as a superior target for gene therapy.
  • To explore the lifelong therapeutic gene delivery capabilities of HSCs.

Main Methods:

  • Review of current gene therapy strategies utilizing marrow cells.
  • Analysis of hematopoietic stem cell properties, including self-replication and differentiation potential.

Main Results:

  • Hematopoietic stem cells demonstrate significant potential as a lifelong source of therapeutic genes.
  • HSCs can generate blood cells across all lineages, addressing a wide range of genetic disorders.

Conclusions:

  • Hematopoietic stem cells represent a highly promising target for gene therapy, offering sustained therapeutic benefits.
  • The versatility of HSCs may pave the way for utilizing embryonic stem cells in future gene therapies.

Related Experiment Videos