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Related Experiment Videos

A two-compartment model for zinc in humans.

W S Watson1, K G Mitchell, T D Lyon

  • 1Nuclear Medicine Department, Southern General Hospital NHS Trust, Glasgow, Scotland, UK.

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
|December 28, 1999
PubMed
Summary

This study measured oral zinc absorption in adults using 65Zn, finding it to be 20%. A simple model accurately estimated total body zinc and turnover, correlating with lean body mass.

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Area of Science:

  • Human Nutrition
  • Trace Element Metabolism
  • Radiotracer Kinetics

Background:

  • Zinc is an essential trace element crucial for numerous physiological processes.
  • Accurate assessment of zinc absorption and body stores is vital for understanding nutritional status.
  • Previous studies often employed complex models or stable isotopes for zinc kinetics.

Purpose of the Study:

  • To quantify oral zinc absorption from a mixed meal in healthy adults.
  • To determine total body zinc (TBZn) and zinc turnover using a simple compartmental model.
  • To evaluate the correlation between TBZn and lean body mass.

Main Methods:

  • Oral administration of the radiotracer 65Zn in a test meal (beef, potatoes, peas).
  • Measurement of 65Zn absorption percentage in 19 healthy adults.

Related Experiment Videos

  • Longitudinal whole-body and whole-blood retention tracking in 9 subjects.
  • Analysis using a two-compartment model to estimate TBZn and zinc turnover.
  • Correlation analysis with total body potassium (40K) for lean body mass estimation.

    • Main Results:

    • Oral zinc absorption was determined to be 20% +/- 5%.
    • TBZn ranged from 15.5 to 35.9 mmol, with zinc turnover from 0.043 to 0.073 mmol/d.
    • A strong correlation was observed between TBZn and total body potassium.
    • The rapidly exchanging zinc pool was estimated between 3.2 and 5.6 mmol.

    Conclusions:

    • A simple radiotracer method and compartmental model effectively estimate short- and long-term zinc behavior in the body.
    • The findings align with results from more complex radiotracer and stable isotope studies.
    • This approach provides valuable insights into zinc metabolism and body burden in humans.