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[Protection of reproduction function in women with Hodgkin's disease in the course of polychemotherapy]
Terapevticheskii Arkhiv
|December 28, 1999
Abstract
Aim:
To evaluate efficiency of estrogen-gestagen treatment for protection of the ovaries during polychemotherapy.
Materials And Methods:
Ultrasonography of the pelvic organs, radioimmunoassay of LH, FSH, prolactin, E2, testosterone were performed in 95 women of child-bearing age with different stages of Hodgkin's disease.
Results:
Cytostatic therapy of Hodgkin's disease had ovariotoxic effects and led to amenorrhea in 83% of the examinees. Regular estrogen-gestagen treatment protected ovaries in 86% of the patients.
Conclusion:
It is recommended for women to take estrogen-gestagen drugs to protect ovaries during polychemotherapy of Hodgkin's disease.