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Improvement of pulmonary preservation with Celsior and Perfadex: impact of storage time on early post-ischemic lung
T Wittwer1, T Wahlers, A Fehrenbach
1Department of Cardiothoracic and Vascular Surgery, Hannover Medical School, Germany. Th.Wittwer-MD@t-online.de
Background:
Optimal preservation of post-ischemic organ function is a continuing challenge in clinical lung transplantation.
Methods:
Using an established extracorporeal rat lung screening model, the results after preservation of 8 lungs, each with the extracellular-type preservation solutions Celsior and Perfadex using ischemic periods of 2 and 4 hours were compared to the results obtained after 2 hours of preservation with low-potassium Euro-Collins with prostacyclin.
Results:
Oxygenation capacity of all Celsior-preserved organs was significantly higher as compared to LPEC lungs (p < 0.01), and after 4 hours of ischemia, lung preservation in terms of post-ischemic oxygenation ability was significantly higher in the Celsior group compared with Perfadex-protected organs (p < 0.01).
Conclusion:
Especially at extended ischemic times Celsior can provide significantly better pulmonary preservation in terms of oxygenation capacity compared to Perfadex solution, which is associated with a post-ischemic lung function only comparable to preservation with modified Euro-Collins solution.