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Blockers of human T cell Kv1.3 potassium channels using de novo ligand design and solid-phase parallel combinatorial
1Department of Chemistry, University of California, Irvine 92697, USA.
Bioorganic & Medicinal Chemistry Letters
|December 28, 1999
Abstract:
Blockers of the human Kv1.3 potassium channel were designed using Biosym/MSI's ligand design program LUDI. Parallel combinatorial synthesis of the resultant substituted phenyl-stilbenes on solid phase, followed by 125I Charybdotoxin (125I ChTx) screening, yielded 12 Kv1.3 channel blockers with modest activity.