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Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice
Published on: October 27, 2014
A one-step synthesis of a deuterated paclitaxel analogue: 10-deacetoxy-(10alpha-2H)paclitaxel
D Dutta1, H Hadd, D G Vander Velde
1Department of Medicinal Chemistry, University of Kansas, Lawrence 66045, USA.
Bioorganic & Medicinal Chemistry Letters
|December 28, 1999
Abstract:
10-Deacetoxy-(10alpha-2H)paclitaxel was prepared in one step via the samarium diiodide mediated deoxygenation of paclitaxel in the presence of D2O.

