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A one-step synthesis of a deuterated paclitaxel analogue: 10-deacetoxy-(10alpha-2H)paclitaxel

D Dutta1, H Hadd, D G Vander Velde

  • 1Department of Medicinal Chemistry, University of Kansas, Lawrence 66045, USA.

Bioorganic & Medicinal Chemistry Letters
|December 28, 1999
PubMed

Abstract:

10-Deacetoxy-(10alpha-2H)paclitaxel was prepared in one step via the samarium diiodide mediated deoxygenation of paclitaxel in the presence of D2O.

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Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...

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