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Eye disorder database "KMeyeDB".

S Minoshima1, S Mitsuyama, S Ohno

  • 1Center for Genomic Medicine, Department of Molecular Biology, Keio University School of Medicine, Tokyo, Japan.

Human Mutation
|December 29, 1999
PubMed
Summary
This summary is machine-generated.

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KMeyeDB is a new database for human eye disorder gene mutations. It uses MutationView software to display and analyze mutations in the RB-1 gene, crucial for retinoblastoma development.

Area of Science:

  • Ophthalmology
  • Genetics
  • Bioinformatics

Background:

  • Human eye disorders are often caused by mutations in specific genes.
  • Retinoblastoma, a malignant retinal tumor, is linked to mutations in the RB-1 gene.
  • Databases are essential for organizing and analyzing genetic mutation data.

Purpose of the Study:

  • To introduce KMeyeDB, a novel database for human eye disorder gene mutations.
  • To demonstrate the utility of KMeyeDB and its MutationView software for analyzing RB-1 gene mutations.
  • To provide a graphical presentation of mutation data for retinoblastoma research.

Main Methods:

  • Development of the KMeyeDB database.
  • Utilization of MutationView software for data visualization and analysis.

Related Experiment Videos

  • Focus on mutations within the RB-1 gene associated with retinoblastoma.

    • Main Results:

    • KMeyeDB provides a user-friendly interface for accessing mutation data.
    • MutationView enables graphical analysis of mutation patterns in eye disorder genes.
    • Specific display windows for RB-1 gene mutations in retinoblastoma are presented.

    Conclusions:

    • KMeyeDB is a valuable resource for researchers studying eye disorder genetics.
    • The MutationView software enhances the analysis and understanding of gene mutations.
    • KMeyeDB facilitates research into the pathogenesis of retinoblastoma through detailed mutation analysis.