An e-mail system for obtaining approval to use a restricted agent
Related Experiment Video
Updated: Jul 28, 2026

Facile and Efficient Preparation of Tri-component Fluorescent Glycopolymers via RAFT-controlled Polymerization
Published on: June 19, 2015
1Harvard Medical School and Endocrinology-Hypertension Division, Boston, MA, USA.
Abstract:
Because of concerns over cost, proper patient selection, and prescribing patterns, pharmacy and therapeutics committees must be very selective about which new medications can be added to formularies and used in health systems. However, in the final analysis, many problems with important new agents are easily solved when clinicians select the right patients and prescribe these agents properly. Physician specialists in appropriate fields often already know about important new medications from clinical trials, professional meetings, and published articles. In such cases, these specialists can help with the needed diffusion of information to other physicians so that a broad range of prescribers in a health system become familiar with the new agent, its advantages, what types of patients need the drug, and what problems may be encountered.
Related Concept Videos
Drugs Acting on Autonomic Ganglia: Blockers
Adrenergic Agonists: Direct-Acting Agents
These agents can be classified...
Adrenergic Agonists: Indirect-Acting Agents
One mechanism involves depleting stored catecholamines by displacing them from synaptic vesicles. These agents, known as "displacers," are transported into vesicles at the expense of noradrenaline. Examples include amphetamine and tyramine, which lack a catechol moiety, resulting in prolonged action, improved oral bioavailability, and...
Adrenergic Agonists: Mixed-Action Agents
Ephedrine and pseudoephedrine lack a catecholamine group, making them less susceptible to degradation by metabolic enzymes. They have increased oral bioavailability and lipophilicity, resulting in a longer duration of action. Their response is reduced by...
Adrenergic Antagonists: Chemistry and Classification of ɑ-Receptor Blockers
Nonselective α-blockers: Nonselective α-blockers contain haloalkylamine or imidazoline moieties. Phenoxybenzamine, with a haloalkylamine...
Adrenergic Antagonists: Pharmacological Actions of ɑ-Receptor Blockers
α1-blockers: These drugs inhibit α1-adrenoceptors on smooth muscle cells, resulting in vasodilation. This vasodilation lowers blood pressure, making α1-blockers valuable in treating hypertension. Additionally, α1-blockers effectively address urinary obstruction...

