Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pharmacology.

K P Lewis1, G D Stanley

  • 1Department of Anesthesia, Boston University Medical Center, MA 02118, USA.

International Anesthesiology Clinics
|December 30, 1999
PubMed
Summary
This summary is machine-generated.

Maintaining patient comfort during intravenous conscious sedation (IVCS) is key. Avoid deep sedation by carefully managing drug doses, considering patient risk factors, and monitoring for complications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Commonplace reminders to the general anesthetist.

Clinical medicine (Northfield, Ill.)·2010
Same author

Sequelae of Intraspinal Anaesthesia.

Canadian Medical Association journal·2010
Same author

Dr. Michael Clark.

Canadian Medical Association journal·2010
Same author

A Miscellany of Anaesthesia Bugbears.

Canadian Medical Association journal·2010
Same author

Treatment of Asthma.

Canadian Medical Association journal·2010
Same author

Medical pioneering in Alberta; Dr. Edward M. Sharpe.

Historical bulletin; notes and abstracts dealing with medical history·2010
Same journal

Regional Anesthesia for Hip Fracture Surgery in Frail Adults: Primary Anesthetic and Perioperative Analgesic Approaches.

International anesthesiology clinics·2026
Same journal

The Transition of Total Joint Arthroplasty From Inpatient to Ambulatory Surgery Centers: Evolution, Evidence, and Implications.

International anesthesiology clinics·2026
Same journal

Patient Blood Management in Orthopedic Surgery.

International anesthesiology clinics·2026
Same journal

The Practitioner's Guide to Upper Extremity Nerve Blocks.

International anesthesiology clinics·2026
Same journal

Anesthetic Challenges and Strategies in Pediatric Spine Surgery.

International anesthesiology clinics·2026
Same journal

Development of a Preoperative Physical Frailty-associated Screening Process: A Quality Improvement Initiative.

International anesthesiology clinics·2026
See all related articles

Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Intravenous conscious sedation (IVCS) aims for patient comfort without compromising vital functions.
  • Deep sedation, characterized by loss of protective reflexes and unresponsiveness, is a complication to be avoided.

Purpose of the Study:

  • To emphasize patient risk factors and drug considerations for safe IVCS.
  • To guide clinicians in preventing deep sedation and its associated complications.

Main Methods:

  • Review of drug metabolism, excretion, and potential interactions relevant to IVCS.
  • Identification of patient populations at increased risk for adverse sedation effects.

Main Results:

  • Elderly patients, those with COPD, low serum albumin, or poor cardiac function require dose adjustments.

Related Experiment Videos

  • Drugs with active metabolites (e.g., diazepam, meperidine) or those with prolonged effects (e.g., fentanyl) necessitate careful titration.
  • Drug interactions (e.g., cimetidine with diazepam) can prolong sedation.

    • Conclusions:

    • Safe IVCS requires careful drug titration, awareness of patient-specific risk factors, and understanding of pharmacokinetic principles.
    • Maintaining a patent airway and responsiveness is paramount, achievable with vigilant monitoring and appropriate drug management.