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Related Experiment Videos

External quality control program of four blood cell counters.

A Rosas-Baruch1, R Salas-Montiel, A Loria

  • 1Departamento de Control de Calidad, Instituto Nacional de la Nutrición Salvador Zubirán. arbaruch@aztlan.innsz.mx

Revista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La Nutricion
|December 30, 1999
PubMed
Summary

An internal quality control program improved automated blood cell counter accuracy for recalibratable parameters. However, significant differences in red-cell distribution width between counters require specific reference ranges for clinical interpretation.

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Area of Science:

  • Clinical laboratory science
  • Hematology automation
  • Quality control in diagnostics

Background:

  • Automated hematology analyzers are crucial for blood cell counting.
  • Internal quality control (IQC) programs are essential for maintaining analyzer performance.
  • Evaluating the effectiveness of IQC programs is vital for reliable diagnostic results.

Purpose of the Study:

  • To assess the efficacy of an internal-external quality control program for four automated hematology counters.
  • To determine the impact of the IQC program on parameter accuracy and inter-analyzer concordance.

Main Methods:

  • Six direct cell parameters were measured bi-weekly over 14 months using three fresh blood samples on four Coulter counters.
  • Daily medians were used to detect inaccuracies, triggering recalibration if confirmed by the internal control program.

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  • Parameters included leukocyte and erythrocyte counts, hemoglobin, red-cell volume, platelet volume, and red-cell distribution width.

    • Main Results:

    • The internal control program confirmed inaccuracies in 21 of 22 instances, leading to recalibration.
    • Recalibration successfully improved accuracy and concordance for parameters like leukocyte count, erythrocyte count, hemoglobin, and red-cell volume.
    • Significant inter-counter differences (up to 9%) were observed for non-recalibratable parameters, specifically platelet volume and red-cell distribution width.

    Conclusions:

    • The evaluated IQC program effectively enhanced accuracy and precision for recalibratable parameters within and between automated counters.
    • Substantial variations in red-cell distribution width among counters necessitate the establishment of counter-specific reference ranges to avoid clinical misinterpretation.
    • Continuous monitoring and recalibration are crucial for maintaining the reliability of hematology diagnostic parameters.