Related Experiment Video
Updated: Jul 25, 2026

05:08
Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
Published on: January 31, 2022
Side effects of alternative iron supplementation: a pilot study
1Center for Nursing Research, Penn State Geisinger Health System's, Milton S. Hershey Medical Center, USA.
Summary
This study shows that nurse-led home visits and alternate iron supplements effectively improved hematocrit levels in homeless women with iron deficiency anemia. Fatigue also decreased, with minimal side effects reported.
Area of Science:
- Public Health
- Hematology
- Nursing Interventions
Background:
- Iron deficiency anemia (IDA) is a prevalent health issue, particularly affecting women.
- Homeless women represent a vulnerable population at high risk for IDA.
- Effective interventions are needed to manage IDA in underserved communities.
Purpose of the Study:
- To evaluate the efficacy of an intervention combining home visits by a nurse and alternate iron supplementation for women with IDA.
- To assess changes in hematocrit levels and the incidence of side effects.
Main Methods:
- A longitudinal study involving ten African-American homeless women in transitional housing.
- Participants received weekly and monthly nurse home visits over a three-month period.
- Encouraged daily intake of alternate iron supplements.
Main Results:
- Significant increase in hematocrit values from baseline to three months (p < .0001).
- Significant decrease in reported fatigue from baseline to three months (p = .015).
- Minimal gastrointestinal side effects reported, with constipation occurring infrequently.
Conclusions:
- Nurse-led home visits combined with alternate iron supplements are effective in improving hematocrit levels and reducing fatigue in homeless women with IDA.
- The intervention demonstrates a favorable safety profile with low incidence of adverse effects.
- This model holds promise for broader application in populations susceptible to anemia and constipation, such as the elderly and pregnant women.
Related Concept Videos
Bioavailability Study Design: Single Versus Multiple Dose Studies
Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
Bioavailability Study Design: Healthy Subjects Versus Patients
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...

