Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Strain-specific white-spotting patterns in laboratory mice.

M L Lamoreux1

  • 1Department of Veterinary Pathobiology, Texas A&M University, College Station 77843, USA. llamoreux@cvm.tamu.edu

Pigment Cell Research
|December 30, 1999
PubMed
Summary

Genetic background significantly influences white spotting patterns in mice, affecting the location of pigment cell absence. Different mouse strains show varied spotting locations, revealing new genetic influences on melanocyte development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of a large deletion of the basic domain of mi transcription factor on differentiation of mast cells.

Blood·2001
Same author

Interaction of major coat color gene functions in mice as studied by chemical analysis of eumelanin and pheomelanin.

Pigment cell research·2001
Same author

Importance of leucine zipper domain of mi transcription factor (MITF) for differentiation of mast cells demonstrated using mi(ce)/mi(ce) mutant mice of which MITF lacks the zipper domain.

Blood·2001
Same author

The melanocortin 1 receptor is the principal mediator of the effects of agouti signaling protein on mammalian melanocytes.

Journal of cell science·2001
Same author

The inbred mouse in pigmentation research: significance of a congenic developmental system.

Pigment cell research·2001
Same author

Mutant alleles at the brown locus encoding tyrosinase-related protein-1 (TRP-1) affect proliferation of mouse melanocytes in culture.

Pigment cell research·2000

Area of Science:

  • Developmental biology
  • Genetics
  • Mammalian pigmentation

Background:

  • White spotting is characterized by the absence of melanocytes (pigment cells) from normal body locations.
  • This phenomenon can result from melanoblast apoptosis or migration failures, which can be melanocyte- or environment-specific.
  • Several genetic loci, including W (kit), piebald (s), patch (Ph), dominant spotting (W(J2)), rumpwhite (Rw), and belted (bt), are known to be involved in white spotting.

Purpose of the Study:

  • To investigate how different genetic backgrounds (inbred strains) influence white spotting patterns.
  • To determine if genetic loci affect the location of white spots in addition to their extent.
  • To compare white spotting phenotypes across different mutant alleles on C57BL/6 (B6) and JU/CtLm (JU) mouse strains.

Main Methods:

Related Experiment Videos

  • Examined white spotting patterns in mice carrying mutations at the piebald (s), patch (Ph), dominant spotting (W(J2)), rumpwhite (Rw), or belted (bt) loci.
  • Compared phenotypes of these mutants when backcrossed onto two distinct inbred strains: C57BL/6 (B6) and JU/CtLm (JU).
  • Analyzed the location and extent of white spots in relation to the genetic background.

Main Results:

  • Genetic background significantly influences the location of white spotting.
  • On the JU background, piebald, patch, and dominant-spotted mutations resulted in more anterior spotting compared to the B6 background.
  • The rumpwhite mutation showed the opposite pattern, with more anterior spotting on the B6 background than on JU.
  • The belted mutation's spotting pattern was not affected by the background genome.

Conclusions:

  • Multiple genetic loci influence both the size and the location of white spots.
  • The interaction between specific mutant alleles and the background genome determines the precise spotting pattern.
  • These findings highlight the importance of genetic background in studying developmental phenotypes related to melanocyte}}$.
  • Meta_Description:
  • Investigating how genetic background affects white spotting in mice, revealing new loci influencing pigment cell absence patterns and locations.