Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Models of receptive-field dynamics in visual cortex.

G J Kalarickal1, J A Marshall

  • 1Department of Computer Science, University of North Carolina at Chapel Hill, USA. kalarick@cs.unc.edu

Visual Neuroscience
|December 30, 1999
PubMed
Summary

This study models how visual receptive fields adapt after damage, finding that specific synaptic plasticity rules best explain observed changes in adult animals. These findings advance our understanding of visual system recovery and learning.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genotype analysis of noroviruses associated with gastroenteritis outbreaks in childcare centres, Victoria, Australia, 2012-2015.

Epidemiology and infection·2017
Same author

Norovirus genotype diversity associated with gastroenteritis outbreaks in aged-care facilities.

Epidemiology and infection·2015
Same author

Evaluation of the RIDAGENE real-time PCR assay for the detection of GI and GII norovirus.

Diagnostic microbiology and infectious disease·2014
Same author

Emergence of GII.e as a major ORF 1 norovirus genotype and its associated ORF 2 GII.4 variant forms.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases·2014
Same author

Altered patterns of norovirus GII.b recombinant forms in gastroenteritis outbreaks in Victoria, Australia, 2002-2005 compared to 2006-2011.

Journal of medical virology·2013
Same author

Cryptosporidium species in calves submitted for postmortem examination in England and Wales.

The Veterinary record·2011

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Vision Science

Background:

  • Cortical receptive fields (RFs) dynamically change size and shape following visual system damage, such as artificial scotoma conditioning or retinal lesions.
  • These RF dynamics are crucial for adaptive recovery from visual deficits, optimizing processing efficiency, and enabling perceptual learning.

Purpose of the Study:

  • To present and analyze the afferent excitatory (EX) and lateral inhibitory (IN) synaptic plasticity rules (EXIN rules) for modeling persistent RF changes.
  • To compare the EXIN model with the LISSOM and neuronal adaptation models in simulating adult cortical RF dynamics.

Main Methods:

  • Developed the EXIN rules, incorporating both excitatory and inhibitory synaptic plasticity.
  • Isolated and analyzed individual rules within the EXIN, LISSOM, and neuronal adaptation models.

Related Experiment Videos

  • Conducted computer simulations to compare model predictions with neurophysiological data.

    • Main Results:

    • The EXIN lateral inhibitory rule and LISSOM lateral excitatory rule best matched experimental data on RF changes, including position, shape, and directional shifts.
    • Models accurately predicted the return of responsiveness to silenced cortex and changes with blank stimuli.
    • Observed a lack of dynamic RF changes when conditioning involved a retinal lesion with the unlesioned eye open.

    Conclusions:

    • Specific synaptic plasticity rules, particularly lateral inhibition in EXIN and lateral excitation in LISSOM, are key drivers of adult cortical RF dynamics.
    • The study proposes a "complementary scotoma" experiment to further differentiate between EXIN and LISSOM model predictions.
    • Findings provide insights into the mechanisms underlying visual system adaptation and recovery from damage.