Related Experiment Videos
Loss of atheroprotective effect of estradiol in immunodeficient mice
R Elhage1, S Clamens, C Reardon-Alulis
1INSERM U397, Institut L. Bugnard, Toulouse, France.
Endocrinology
|December 30, 1999
Abstract:
Estradiol significantly decreases fatty streak formation in the aortic root of chow-fed apolipoprotein E-deficient mice. In contrast, immunodeficient mice with homozygous disruption at the recombinase activating gene 2 loci present fatty streak development that is insensitive to estradiol. Lymphocytes thus appear to be required for development of the atheroprotective effect of estradiol in this mouse model.