Related Experiment Video
Updated: Aug 12, 2026

Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells
Published on: March 9, 2012
Potential mechanism for bradykinin-activated and inositol tetrakisphosphate-dependent Ca2+ influx by Ras and GAP1 in
H Higashida1, M Taketo, H Takahashi
1Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Japan. haruhiro@med.kanazawa-u.ac.jp
Abstract:
Here we propose a molecular model for bradykinin receptor-operated and second messenger (inositol-1,3,4,5-tetrakisphosphate)-evoked Ca2+ influx and its potentiation by oncogenic Ras, which is not store-depletion-induced, so-called capacitative, Ca2+ influx. The principal idea for this hypothesis stems from observation that two bradykinin B2 receptor-activated signal pathways, protein tyrosine phosphorylation and formation of inositol tetrakisphosphate, merge during the Ca2+ influx process and that GTPase activating-protein 1 (GAP 1) is inositol tetrakisphosphate binding protein.
More Related Videos
Related Concept Videos
The Ras Gene
Ras is a superfamily...
Amplifying Signals via Second Messengers
Small GTPases - Ras and Rho
Three regulatory proteins control their activity:
MAPK Signaling Cascades
IP3/DAG Signaling Pathway
Intracellular Signaling Affects Focal Adhesions
Some...

