Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Comparative blood coagulation studies in the ostrich.

C L Frost1, R J Naudé, W Oelofsen

  • 1Department of Biochemistry and Microbiology, University of Port Elizabeth, South Africa.

Immunopharmacology
|December 30, 1999
PubMed
Summary

The ostrich blood coagulation system differs significantly from mammals, lacking several key clotting factors like Factor VII and Factor IX. This study highlights unique aspects of avian hemostasis compared to other vertebrates.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Venous thromboembolism prevention in South Africa: Bridging the gap between guidelines and practice.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2025
Same author

The Use of venous thromboembolism prophylaxis in relatioN to patiEnt risk profilINg (TUNE IN) Wave 3 study.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2025
Same author

Thrombosis and bleeding outcomes with warfarin conversion to rivaroxaban during the COVID-19 pandemic.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2025
Same author

Right heart echocardiography findings in hypoxic pneumonia patients during the COVID-19 pandemic in a South African population.

European heart journal. Imaging methods and practice·2024
Same author

Toward an integrated multi-gigahertz ionizing particle diagnostic.

The Review of scientific instruments·2024
Same author

The J&J COVID-19 vaccine: Fit for purpose in our setting.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2021

Area of Science:

  • Comparative physiology
  • Hemostasis and thrombosis
  • Avian biology

Background:

  • Understanding blood coagulation across species is crucial for comparative physiology and veterinary medicine.
  • The ostrich (Struthio camelus) represents a unique avian model for studying hemostatic differences.

Purpose of the Study:

  • To compare the blood coagulation system of ostriches with mammalian, avian, and reptilian models.
  • To identify specific coagulation factors and markers present or absent in ostrich plasma.

Main Methods:

  • Analysis of international normalised ratio (INR), partial thromboplastin time (PTT), and thrombin time in ostrich plasma.
  • Quantification of coagulation factors (e.g., Factor X, antithrombin III, prothrombin) and kallikrein system markers using human substrates and chromogenic substrates.

Related Experiment Videos

  • Isolation of thromboplastin from brain and lung tissues for activity assessment.

    • Main Results:

    • Ostrich plasma exhibited elevated INR, PTT, and thrombin time compared to human standards.
    • Factors VII, IX, X, XI, and XII were found to be absent in ostrich plasma.
    • Ostrich plasma showed lower thromboplastic activity than human standards but was comparable to avian and reptilian values, with specific percentages for Factor X, antithrombin III, prothrombin, alpha2-antiplasmin, and plasma kallikrein relative to human plasma.

    Conclusions:

    • The ostrich coagulation system is less complex than the human system, lacking several critical coagulation factors.
    • These findings suggest a distinct evolutionary path for hemostasis in ostriches compared to mammals.