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Related Experiment Videos

Oxytocin administration prolongs luteal function in cyclic mares.

T A Stout1, G E Lamming, W R Allen

  • 1University of Cambridge, Department of Clinical Veterinary Medicine, UK.

Journal of Reproduction and Fertility
|January 1, 2000
PubMed
Summary

Continuous oxytocin administration in mares prevents luteolysis (corpus luteum breakdown). Responsiveness to oxytocin, crucial for prostaglandin F2 alpha release, develops around day 10 of dioestrus.

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Area of Science:

  • Reproductive endocrinology
  • Comparative physiology

Background:

  • Oxytocin and its endometrial receptor are vital for prostaglandin F2 alpha release, which causes luteolysis in mares and ruminants.
  • Understanding the precise timing of oxytocin's role in luteolysis is crucial for reproductive management.

Purpose of the Study:

  • To investigate the role of continuous oxytocin administration in preventing luteolysis in mares.
  • To determine the onset of endometrial oxytocin responsiveness during the estrous cycle.

Main Methods:

  • Continuous subcutaneous infusion of oxytocin or saline via minipump in mares from days 8-20 post-ovulation.
  • Monitoring for the occurrence of luteolysis in treated and control groups.
  • Comparing luteolysis timing when oxytocin administration was initiated on day 8 versus day 10 post-ovulation.

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Main Results:

  • Continuous oxytocin administration from day 8 post-ovulation abolished luteolysis in 80% of mares.
  • Control mares exhibited normal luteolysis.
  • Initiating oxytocin infusion on day 10 post-ovulation led to rapid luteolysis in 40% of mares.

Conclusions:

  • Continuous oxytocin administration effectively prevents luteolysis in mares.
  • Endometrial oxytocin responsiveness, essential for prostaglandin F2 alpha-mediated luteolysis, begins to develop around day 10 of dioestrus in cyclic mares.