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Three cases of macroprolactinaemia.

A O Olukoga1, T L Dornan, J W Kane

  • 1Department of Clinical Biochemistry, Hope Hospital, Salford, UK. AOlukoga@hotmail.com

Journal of the Royal Society of Medicine
|January 1, 2000
PubMed
Summary

Macroprolactinaemia, a condition with high prolactin levels, can persist despite treatment for pituitary adenomas. Early testing is recommended for women with hyperprolactinaemia, especially those with normal cycles.

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Area of Science:

  • Endocrinology
  • Reproductive Medicine

Background:

  • Hyperprolactinaemia, often caused by pituitary adenomas, can lead to symptoms like hirsutism.
  • Treatment resistance and surgical outcomes for prolactinomas can be variable.

Observation:

  • A case study details a woman with persistent hyperprolactinaemia and hirsutism, initially treated for a pituitary microadenoma.
  • Despite bromocriptine therapy and pituitary surgery, hyperprolactinaemia persisted for 15 years.

Findings:

  • Macroprolactinaemia was diagnosed in a patient with persistent hyperprolactinaemia, explaining treatment resistance.
  • This condition may contribute to the failure rate of pituitary surgery for prolactinomas.
  • Two additional cases linked macroprolactinaemia to menstrual irregularities and hormonal imbalances.

Implications:

  • Testing for macroprolactinaemia is advisable in women with hyperprolactinaemia, particularly those with regular ovulatory cycles.
  • Dopamine agonist therapy effectively managed macroprolactinaemia and restored normal menstrual cycles in affected individuals.

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