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Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
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Annual report of the Australian Meningococcal Surveillance Programme, 1998. The Australian Meningococcal Surveillance

    Communicable Diseases Intelligence
    |January 1, 2000
    PubMed

    Insights

    Meningococcal disease surveillance in 1998 found serogroup B and C strains predominated. Most isolates showed decreased susceptibility to penicillin antibiotics, with few resistant to other drugs.

    Area of Science:

    • Microbiology
    • Epidemiology
    • Infectious Diseases

    Background:

    • The National Neisseria Network has monitored meningococcal isolates since 1994.
    • Meningococcal disease remains a significant public health concern.

    Purpose of the Study:

    • To determine the phenotype and antibiotic susceptibility of Neisseria meningitidis isolates from invasive cases in 1998.
    • To identify dominant serogroups and antimicrobial resistance patterns.

    Main Methods:

    • Laboratory-based surveillance of 323 invasive meningococcal disease isolates.
    • Phenotypic characterization (serogroup, serotype, serosubtype).
    • Antibiotic susceptibility testing using minimum inhibitory concentration (MIC).

    Main Results:

    • Serogroup B and C isolates comprised 90% of all invasive strains.
    • Serogroup B predominated nationally, while Serogroup C was prominent in New South Wales, particularly in adolescents and young adults.
    • C:2a:P1.5 was the most common phenotype; C:2b:P1.5,2 strains were also widespread.
    • Approximately 75% of isolates exhibited decreased susceptibility to penicillin antibiotics (MIC 0.06–0.5 mg/L).
    • Reduced susceptibility was noted for rifampicin (4 isolates), ciprofloxacin (1 isolate), and chloramphenicol (1 isolate).

    Conclusions:

    • Serogroup B and C Neisseria meningitidis are the primary causes of invasive meningococcal disease.
    • Decreased penicillin susceptibility is a significant finding, necessitating ongoing surveillance.
    • Emerging resistance to other antibiotics is minimal but warrants monitoring.

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