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[Prospective neurological analysis of development of children of mothers with IDDM]
G Ircha1, M Zawodniak-Szałapska, K Cypryk
1Kliniki Neurologii Instytutu CZMP w Lodzi.
Insights
Children born to mothers with diabetes type 1 (DM1) show higher rates of central nervous system (CNS) damage and dysfunction. Early diagnosis is crucial for better outcomes in these infants.
Area of Science:
- Neurology
- Endocrinology
- Pediatrics
Background:
- Maternal diabetes type 1 (DM1) poses risks to fetal development.
- Understanding the impact of DM1 on offspring neurological health is critical.
Purpose of the Study:
- To enable early diagnosis of central nervous system (CNS) damage and dysfunction in infants of mothers with DM1.
- To analyze the relationship between maternal diabetes control and fetal-perinatal complications with the neurological status of offspring.
Main Methods:
- Neurological examinations were conducted on 35 children of mothers with DM1 and 109 controls.
- Examinations occurred at multiple time points: 3, 6, 9, 12, and 18 months of age.
Main Results:
- Four children of DM1 mothers exhibited CNS damage (cerebral palsy, psychomotor delay).
- Nine children of DM1 mothers displayed minor neurological dysfunction ('soft' signs).
- Control group showed lower incidence of cerebral palsy and minor neurological dysfunction.
Conclusions:
- Infants born to mothers with DM1 experience more frequent and severe CNS dysfunctions.
- Neurological disorder severity correlates with maternal diabetes control, complications, and neonatal factors like prematurity and hypoglycemia.
Unlabelled:
Aim of the study was early diagnosis of CNS damage and dysfunction in the progeny of women with diabetes type 1 (DM1). Interdependencies between the course of diabetes in mothers and fetal-perinatal complications and neurological state of the progeny were also analysed. 35 children of mothers with DM1 and 109 in control group underwent neurological examinations at the age of 3, 6, 9, 12 and 18 months.
Results:
In the group of children of DM1 mothers four had symptoms of CNS damage such as cerebral palsy or psychomotor delay. In the remaining 9 children so-called "soft" neurological signs or minor neurological dysfunction were found. In control group 1 had a light form of cerebral palsy and 3 had symptoms of minor neurological dysfunction. The dependencies of frequency and gravity of neurological disorders in children on diabetes metabolic control and complications and hypoxemic-ischemic states, prematurity, macrosomia and hypoglycemia in newborns was observed.
Conclusion:
The symptoms of CNS dysfunctions are more frequent and more serious in children of DM1 mothers than in control group.